منابع مشابه
The Low Noise Limit in Gene Expression
Protein noise measurements are increasingly used to elucidate biophysical parameters. Unfortunately noise analyses are often at odds with directly measured parameters. Here we show that these inconsistencies arise from two problematic analytical choices: (i) the assumption that protein translation rate is invariant for different proteins of different abundances, which has inadvertently led to (...
متن کاملThe Evaluation of GJB2 Gene Expression in the Cochlear Tissue Exposed to White Noise
Introduction: One of the most important complications of exposure to noises is changes in the gene expression patterns. Irreversible damage to the inner ear, such as noise-induced hearing loss (NIHL), is caused by tissue damage and changes in the gene expressions in the auditory system. Changes in the GJB2 gene expression pattern lead to autosomal deafness at different loci. The present study a...
متن کاملTuning noise in gene expression
The relative contribution of promoter architecture and the associated chromatin environment in regulating gene expression noise has remained elusive. In their recent work, Arkin, Schaffer and colleagues (Dey et al, 2015) show that mean expression and noise for a given promoter at different genomic loci are uncorrelated and influenced by the local chromatin environment.
متن کاملInvestigating the Effects of Exposure to Continuous White Noise on SLC26A4 Gene Expression Levels in Male Rat Cochlea
Background and purpose: Irreversible damage to the inner ear is known as noise-induced hearing loss (NIHL). Exposure to excessive noise can affect the expression of genes in molecules involved in development of NIHL. SLC26A4 gene or PDS is responsible for causing both syndromic and non-syndromic deafness and is located at DFNB site. The aim of this study was to investigate the expression level ...
متن کاملBalancing noise and plasticity in gene expression
Coupling the control of expression stochasticity (noise) with the capacity to expression change (plasticity) can constrain gene function and limit adaptation. Which factors contribute then to modulate this coupling? Transcription re-initiation is generally associated to coupling and this is commonly related to strong chromatin regulation. We alternatively show how strong regulation can however ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0140969